Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
7
We examined the effects of Secholex, an anion-exchange gel, on high cholesterol in 46 patients with severe hyperlipoproteinemia over various studies. The results revealed that Secholex effectively lowered cholesterol levels, achieving a 15% reduction after the first year and 13% during the second year. While it was less effective than cholestyramine in increasing bile acid excretion, many patients preferred Secholex. However, it’s important to note that a third of patients experienced limited reductions in cholesterol, indicating varying responses.
Read More
9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
Most Useful Reviews
9
Supports cholesterol control
3 people found this helpful
This excellent vitamin is essential for blood formation and nervous system health. It helps with fat burning and controlling cholesterol levels, making it especially important for vegetarians.
Read More
9
Improved cholesterol levels
1 people found this helpful
I drank this on my endocrinologist's recommendation after blood tests revealed anaemia and its effects. After taking it, my blood pressure normalised, cholesterol levels dropped, and I noticed significant improvements in hair loss and regrowth. My ferritin levels also increased noticeably.
Read More
7.5
Boosts energy levels
6 people found this helpful
Methylcobalamin is the most bioavailable form of Vitamin B12, making it easier for my body to absorb. This product gives me energy, especially when taken on an empty stomach. I enjoy the cherry flavour and find the tablets small and easy to consume. I will certainly buy more.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
- All Researches
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
Read More
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
8
We explored the effects of vitamins B12, B6, and folic acid on cholesterol and homocysteine levels in 24 male patients with high triglycerides and cholesterol issues. Over 120 days, patients took specific doses of these vitamins while researchers measured their lipid and homocysteine levels at various intervals.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
Read More
8
We explored how adding plant sterols to orange juice can impact cholesterol levels in mildly hypercholesterolemic individuals. In this study, 72 healthy participants enjoyed either regular orange juice or a fortified version for eight weeks.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports cholesterol control
3 people found this helpful
This excellent vitamin is essential for blood formation and nervous system health. It helps with fat burning and controlling cholesterol levels, making it especially important for vegetarians.
Read More
9
Improved cholesterol levels
1 people found this helpful
I drank this on my endocrinologist's recommendation after blood tests revealed anaemia and its effects. After taking it, my blood pressure normalised, cholesterol levels dropped, and I noticed significant improvements in hair loss and regrowth. My ferritin levels also increased noticeably.
Read More
7.5
Boosts energy levels
6 people found this helpful
Methylcobalamin is the most bioavailable form of Vitamin B12, making it easier for my body to absorb. This product gives me energy, especially when taken on an empty stomach. I enjoy the cherry flavour and find the tablets small and easy to consume. I will certainly buy more.
Read More
9
Improves energy
5 people found this helpful
My father takes this B12 product twice daily as recommended by his doctor for his nervous system. The results have been excellent; he feels calmer and has more energy. We plan to continue using it to maintain these benefits.
Read More
7.5
Reduces homocysteine
2 people found this helpful
I recently learned from a blood test that my high homocysteine may lead to atherosclerosis. I researched and found that vitamin B12, particularly in the methylcobalamin form, can help lower these levels effectively. Health to all!
Read More
Frequently Asked Questions
7.5
Essential vitamin
6 people found this helpful
I chose methylcobalamin B12 from NOW as it is absorbed quickly. It has many benefits, including enhancing immune function and lowering blood cholesterol levels. The pleasant tasting tablets dissolve easily and the course lasts from two to four weeks. It's a vital vitamin for overall health.
0
No increase in levels
4 people found this helpful
Following my doctor's advice, I took this vitamin for 40 days, but my vitamin B12 level dropped instead of increasing. Although it was within normal limits previously, this outcome was disappointing, possibly due to individual factors. The drug may not be at fault, but the experience was disheartening.
7.5
Aids vascular health
1 people found this helpful
I believe this product will greatly assist me in managing my high blood pressure and cholesterol issues. I’m optimistic about its benefits.
9
Improved cholesterol levels
1 people found this helpful
I drank this on my endocrinologist's recommendation after blood tests revealed anaemia and its effects. After taking it, my blood pressure normalised, cholesterol levels dropped, and I noticed significant improvements in hair loss and regrowth. My ferritin levels also increased noticeably.
7.5
Effective cholesterol aid
1 people found this helpful
This is an excellent alternative to injectable vitamin B12! I ordered methylcobalamin from a trusted manufacturer because it absorbs easily. It boosts the immune system, reduces high cholesterol, and supports overall health. I find it beneficial and recommend it for its efficiency.
7.5
Supports nervous system
6 people found this helpful
This vitamin B12 works wonders, especially with high homocysteine when combined with vitamin B9. The taste of the dissolvable tablets is enjoyable, even for children. It calms my nervous system, boosts metabolism, and increases energy levels. However, I advise taking it in the morning due to its energising effects.
9
Improves energy
5 people found this helpful
My father takes this B12 product twice daily as recommended by his doctor for his nervous system. The results have been excellent; he feels calmer and has more energy. We plan to continue using it to maintain these benefits.
7
We examined a multi-ingredient supplement (MIS) featuring red yeast rice and omega-3 fatty acids to see how it impacts cholesterol levels in patients without cardiovascular disease.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
7
B12 treatment shows no significant cholesterol benefit
We explored the effects of a daily combination of plant sterols, fish oil, and B vitamins on cholesterol levels in hypercholesterolemic young individuals over 16 weeks.
While we observed significant reductions in total cholesterol and LDL cholesterol, the impact of B12 treatment specifically did not lead to marked improvements in high cholesterol.
Interestingly, triacylglycerol levels decreased slightly but were not statistically significant. Overall, this evidence suggests that while the combination may help manage cholesterol, B12 does not create a standout difference on its own.
While we observed significant reductions in total cholesterol and LDL cholesterol, the impact of B12 treatment specifically did not lead to marked improvements in high cholesterol.
Interestingly, triacylglycerol levels decreased slightly but were not statistically significant. Overall, this evidence suggests that while the combination may help manage cholesterol, B12 does not create a standout difference on its own.
8
We explored the effects of vitamins B12, B6, and folic acid on cholesterol and homocysteine levels in 24 male patients with high triglycerides and cholesterol issues. Over 120 days, patients took specific doses of these vitamins while researchers measured their lipid and homocysteine levels at various intervals.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
4
B12 effects on cholesterol unclear
We looked into how vitamin B12, along with folic acid, might affect cholesterol levels in a small group of patients. After a 2-week diet, 141 patients were divided into three groups for 6 weeks: one received simvastatin with vitamins, another just simvastatin, and the last solely vitamins.
The results showed that both the combination group and the simvastatin-only group had similar reductions in LDL cholesterol, around 55% and 51% respectively. Additionally, vitamin B12 and folic acid didn't seem to have any negative impact when taken with simvastatin.
However, while the treatment was well-tolerated, vitamin B12’s role in significantly lowering cholesterol remains unclear.
The results showed that both the combination group and the simvastatin-only group had similar reductions in LDL cholesterol, around 55% and 51% respectively. Additionally, vitamin B12 and folic acid didn't seem to have any negative impact when taken with simvastatin.
However, while the treatment was well-tolerated, vitamin B12’s role in significantly lowering cholesterol remains unclear.
References
- Wright N, Wilson L, Smith M, Duncan B, McHugh P. The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutr Diabetes. 2017;7:e256. 10.1038/nutd.2017.3
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.
- Lombardo F, Lunghi R, Pallotti F, Palumbo A, Senofonte G, et al. Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia. Clin Ter. 2013;164:e147. 10.7417/CT.2013.1556
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. 10.1186/1475-2891-12-7
- Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. 10.1016/j.nutres.2009.12.003
- Morón de Salim AR, Garcés Pasamontes A. [Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV]. Arch Latinoam Nutr. 2005;55:28.
- Devaraj S, Jialal I, Vega-López S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler Thromb Vasc Biol. 2004;24:e25.
- MacMahon M, Kirkpatrick C, Cummings CE, Clayton A, Robinson PJ, et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis. 2000;10:195.
- Defraigne JO, Pirenne J, Swinnen JC, Honore P, Jacquet N, et al. [Value and limits of bypassing the distal ileum in the treatment of hypercholesterolemia]. J Chir (Paris). 1990;127:76.
- Nikkila EA, Miettinen TA, Lanner A. Treatment of hypercholesterolemia with Secholex. A long-term clinical trial and comparison with cholestyramine. Atherosclerosis. 1976;24:407.
